Articles I've written

Chrome, ERR_SPDY_PROTOCOL_ERROR, and an invalid HTTP header
August 28, 2017 (updated January 25, 2023)

When migrating your site to a more performant HTTP/2 protocol, it may happen that Chrome will not load a page and will display This site can’t be reached with ERR_SPDY_PROTOCOL_ERROR instead. HTTP/2 is derived from the earlier SPDY protocol, that's probably why the error message doesn't mention HTTP/2 at all. I'll show you how to figure it out with chrome://net-export.

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